Genes and Cardiac Repolarization
نویسندگان
چکیده
منابع مشابه
Genes and cardiac repolarization: the challenge ahead.
Cardiovascular diseases are caused by a combination of environmental and genetic factors.1,2 Deciphering these genetic factors should provide fundamental new insights into their pathogenesis, diagnosis, prevention, and treatment. Previous large-scale association studies have been able to identify patterns of DNA sequence variations that confer susceptibility to cardiovascular diseases3 or alter...
متن کاملMolecular physiology of cardiac repolarization.
The heart is a rhythmic electromechanical pump, the functioning of which depends on action potential generation and propagation, followed by relaxation and a period of refractoriness until the next impulse is generated. Myocardial action potentials reflect the sequential activation and inactivation of inward (Na(+) and Ca(2+)) and outward (K(+)) current carrying ion channels. In different regio...
متن کاملModelling and imaging cardiac repolarization abnormalities.
Repolarization abnormalities, including those induced by the congenital or acquired long QT (LQT) syndrome, provide a substrate for life-threatening cardiac arrhythmias. In this article, we use computational biology to link HERG mutations mechanistically to the resulting abnormalities of the whole-cell action potential. We study how the kinetic properties of I(Ks) (the slow delayed rectifier) t...
متن کاملSudden cardiac arrest associated with early repolarization.
BACKGROUND Early repolarization is a common electrocardiographic finding that is generally considered to be benign. Its potential to cause cardiac arrhythmias has been hypothesized from experimental studies, but it is not known whether there is a clinical association with sudden cardiac arrest. METHODS We reviewed data from 206 case subjects at 22 centers who were resuscitated after cardiac a...
متن کاملDispersion of repolarization in cardiac resynchronization therapy.
BACKGROUND Proarrhythmic effects of cardiac resynchronization therapy (CRT) as a result of increased transmural dispersion of repolarization (TDR) induced by left ventricular (LV) epicardial pacing in a subset of vulnerable patients have been reported. The possibility of identifying these patients by ECG repolarization indices has been suggested. OBJECTIVES The purpose of this study was to te...
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ژورنال
عنوان ژورنال: Circulation
سال: 2005
ISSN: 0009-7322,1524-4539
DOI: 10.1161/circulationaha.105.563015